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Elsevier, Molecular Brain Research, 1-2(118), p. 156-159, 2003

DOI: 10.1016/s0169-328x(03)00335-8

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Activating transcription factor 3 mRNA is upregulated in primary cultures of trigeminal ganglion neurons

Journal article published in 2003 by Gregory O. Dussor, Theodore J. Price ORCID, Christopher M. Flores
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Activating transcription factor 3 (ATF3) has been used in as a marker of nerve injury in primary sensory neurons. The purpose of the present studies was to determine whether primary sensory ganglia in culture express ATF3 and, thus, an injured phenotype. At all time points post-plating (1 h-14 days), neurons in culture expressed ATF3 compared to undetectable expression in native ganglia. In addition, NGF was unable to rescue this injured phenotype. Thus, sensory neurons in culture represent a potential model of injured neurons.