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American Chemical Society, Langmuir, 5(26), p. 2995-2998, 2010
DOI: 10.1021/la904375k
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Thermo-Switching of the Conformation of Genomic DNA in Solutions of Poly(N-isopropylacrylamide)
Journal article published in 2010 by
Ning Chen,
Anatoly A. Zinchenko,
Satoru Kidoaki,
Shizuaki Murata,
Kenichi Yoshikawa 
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Abstract
We used poly(N-isopropylacrylamide) (PNIPAM) to control the conformation of genomic DNA by changing the temperature of a reaction solution and studied the DNA transition at the level of single DNA molecules. With this method, the conformation of long genomic DNA can be readily and reversibly switched between a very compact condensate and an unfolded macromolecule.