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Public Library of Science, PLoS ONE, 2(8), p. e57335, 2013

DOI: 10.1371/journal.pone.0057335

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Iron Oxide Nanoparticle-Micelles (ION-Micelles) for Sensitive (Molecular) Magnetic Particle Imaging and Magnetic Resonance Imaging

Journal article published in 2013 by Gustav J. Strijkers ORCID, Lucas W. E. Starmans, Lwe Luc Starmans, Dirk Burdinski, Nicole P. M. Haex, Npm Nicole Haex, Rik P. M. Moonen, Rpm Rik Moonen ORCID, Gj Gustav Strijkers, K. Klaas Nicolaij, Klaas Nicolay ORCID, Holger Grüll ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Iron oxide nanoparticles (IONs) are a promising nanoplatform for contrast-enhanced MRI. Recently, magnetic particle imaging (MPI) was introduced as a new imaging modality, which is able to directly visualize magnetic particles and could serve as a more sensitive and quantitative alternative to MRI. However, MPI requires magnetic particles with specific magnetic properties for optimal use. Current commercially available iron oxide formulations perform suboptimal in MPI, which is triggering research into optimized synthesis strategies. Most synthesis procedures aim at size control of iron oxide nanoparticles rather than control over the magnetic properties. In this study, we report on the synthesis, characterization and application of a novel ION platform for sensitive MPI and MRI.