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Springer, Nano Research, 7(8), p. 2373-2379, 2015

DOI: 10.1007/s12274-015-0747-5

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X-ray-induced radiophotodynamic therapy (RPDT) using lanthanide micelles: Beyond depth limitations

Journal article published in 2015 by Slávka Kaščáková, Alexandre Giuliani ORCID, Sara Lacerda, Agnès Pallier, Pascal Mercère, Éva Tóth, Eva Jakab-Toth, Matthieu Réfrégiers
This paper is available in a repository.
This paper is available in a repository.

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Abstract

We report lanthanide-based micelles integrating hypericin (Hyp) for X-ray-triggered photodynamic therapy (PDT). The lanthanide luminescence induced by X-ray irradiation excites the photosensitizer, which leads to the generation of singlet oxygen. This versatile approach can be extended to other photosensitizers or other types of liponanoparticles and can allow for magnetic resonance imaging (MRI) guidance. [Figure not available: see fulltext.] © 2015, Tsinghua University Press and Springer-Verlag Berlin Heidelberg.