The Vani Ag prospect is a high-grade epithermal mineralization located along the NW-trending Kondaros-Katsimouti-Vani fault, NW Milos Island, Greece. The prospect is hosted in calc-alkaline dacite domes and volcaniclastic sandstones and represents the NW extension of the Pb-Zn-Ag-Mn Katsimoutis-Kondaros mineralization. It occurs proximal to the Vani exhalative manganese deposit. The Ag content of the prospect is derived from Ag-bearing phases (native silver, argentite/acanthite, silver halides and argentian covellite). Mineralogical evidence like the presence of skeletal habits of sulfides, presence of hydrothermal anglesite, covellite and silver halides that were formed after dissolution of the primary silver and lead-bearing minerals, verifies earlier work that mineralization along the Kondaros-Katsimoutis fault is the product of seawater oxidation and was formed in a submarine setting after reaction of hydrothermal fluids with seawater.