Published in
Bentham Science Publishers, Current Drug Targets, 7(9), p. 532-547
DOI: 10.2174/138945008784911787
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The Potential for Targeting Oncogenic WNT/β -Catenin Signaling in Therapy
Journal article published in 2008 by
Kenneth B. R. Ewan 
,
Trevor C. Dale
,
Trevor C. Dale
This paper is available in a repository.
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Abstract
There has been a surge of interest in the therapeutic targeting of the Wnt pathway following the demonstration that it is activated in a wide variety of tumors and that blocking aberrant signaling promoted tumor cell apoptosis or differentiation. This review describes recent therapeutic approaches and discusses potential opportunities for intervention at multiple levels within the Wnt pathway.