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Wiley, Acta Crystallographica Section a Foundations of Crystallography, s1(58), p. c6-c6, 2002

DOI: 10.1107/s0108767302085343

Elsevier, Cell, 5(108), p. 717-725, 2002

DOI: 10.1016/s0092-8674(02)00660-8

Selected Papers of Michael G Rossmann with Commentaries, p. 317-325

DOI: 10.1142/9789814513357_0037

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Structure of Dengue Virus

Journal article published in 2002 by Richard J. Kuhn, Wei Zhang, Michael G. Rossmann, Sergei V. Pletnev, Jeroen Corver, Edith Lenches, Christopher T. Jones, Suchetana Mukhopadhyay, Paul R. Chipman ORCID, Ellen G. Strauss, Timothy S. Baker, James H. Strauss
This paper is available in a repository.
This paper is available in a repository.

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Abstract

The first structure of a flavivirus has been determined by using a comThe first structure of a flavivirus has been determined by using a combination of cryoelectron microscopy and fitting of the known structure of glycoprotein E into the electron density map. The virus core, within a lipid bilayer, has a less-ordered structure than the external, icosahedral scaffold of 90 glycoprotein E dimers. The three E monomers per icosahedral asymmetric unit do not have quasiequivalent symmetric environments. Difference maps indicate the location of the small membrane protein M relative to the overlaying scaffold of E dimers. The structure suggests that flaviviruses, and by analogy also alphaviruses, employ a fusion mechanism in which the distal β barrels of domain II of the glycoprotein E are inserted into the cellular membrane.