Published in

American Chemical Society, Organic Letters, 6(13), p. 1532-1535, 2011

DOI: 10.1021/ol200221n

Links

Tools

Export citation

Search in Google Scholar

Solomonamides A and B, New Anti-inflammatory Peptides from Theonella swinhoei

Journal article published in 2011 by Carmen Festa ORCID, Simona De Marino, Valentina Sepe, Maria Valeria D’Auria, Giuseppe Bifulco, Cecile Débitus, Mariarosaria Bucci, Valentina Vellecco, Angela Zampella ORCID
This paper is available in a repository.
This paper is available in a repository.

Full text: Download

Green circle
Preprint: archiving allowed
  • Must obtain written permission from Editor
  • Must not violate ACS ethical Guidelines
Upload
Orange circle
Postprint: archiving restricted
  • Must obtain written permission from Editor
  • Must not violate ACS ethical Guidelines
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

Two unprecedented cyclic peptides, solomonamides A and B, were isolated from the marine sponge Theonella swinhoei. The structures were elucidated on the basis of comprehensive 1D and 2D NMR analysis and high-resolution mass spectrometry. A combined approach, involving Marfey's method, QM J based analysis, and DFT J/(13)C calculations, was used for establishing the absolute configuration of the entire molecule. Solomonamide A showed in vivo anti-inflammatory activity.