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American Society for Clinical Investigation, Journal of Clinical Investigation, 12(112), p. 1785-1788

DOI: 10.1172/jci20514

American Society for Clinical Investigation, Journal of Clinical Investigation, 12(112), p. 1785-1788

DOI: 10.1172/jci200320514

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Obesity-induced inflammatory changes in adipose tissue

Journal article published in 2003 by Kathryn E. Wellen ORCID, Gökhan S. Hotamisligil
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Obesity is associated with a state of chronic, low-grade inflammation. Two manuscripts in this issue of the JCI (see the related articles beginning on pages 1796 and 1821) now report that obese adipose tissue is characterized by macrophage infiltration and that these macrophages are an important source of inflammation in this tissue. These studies prompt consideration of new models to include a major role for macrophages in the molecular changes that occur in adipose tissue in obesity.