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Wiley, British Journal of Haematology, 2(154), p. 229-233, 2011

DOI: 10.1111/j.1365-2141.2011.08706.x

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Common genetic variation at 15q25.2 impacts on chronic lymphocytic leukaemia risk

Journal article published in 2011 by Dalemari Crowther-Swanepoel, Maria Chiara Di Bernardo, Krzysztof Jamroziak, Lidia Karabon, Irena Frydecka, Silvia Deaglio, Giovanni D’Arena, Davide Rossi, Gianluca Gaidano, Bianca Olver, Amy Lloyd, Peter Broderick, Luca Laurenti, Zofia Szemraj-Rogucka, Tadeusz Robak and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

A genome-wide association study of chronic lymphocytic leukaemia (CLL) suggested that common variants at 15q25.2 (rs783540) and 18q21.1 (rs1036935) influence CLL. To validate these associations and explore their relationship with CLL risk we genotyped case-control datasets from Poland, UK and Italy totalling 1428 cases and 1920 controls. Combined data from these and previously genotyped series (2503 cases and 5789 controls) provided evidence for an association between 15q25.2 and 18q21.1 loci and CLL risk (P(combined) = 1·10 × 10(-7) and 1·30 × 10(-5) respectively). These data provide further evidence for the involvement of common genetic variants in CLL risk and insight into the biological basis of disease development.