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Wiley, FEBS Letters, 2-3(386), p. 189-193, 1996

DOI: 10.1016/0014-5793(96)00424-3

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Human high affinity, Na+-dependent L-glutamate/L-aspartate transporter GLAST-1 (EAAT-1): Gene structure and localization to chromosome 5p11-p12

Journal article published in 1996 by Wilhelm Stoffel, Jürgen Sasse, Maria Düker, Rolf Müller, Kay Hofmann, Thomas Fink, Peter Lichter
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The gene of the human L-glutamate transporter hGLAST-1 (EAAT-1) has been isolated and characterized. The 1626 bp cDNA open reading frame (542 aa) is distributed over ten exons and at least 85 kb on chromosome 5p11-p12. The gene is unrelated to any other previously described neurotransmitter transporter gene family, but its exon/intron structure corresponds largely to that of the Na(+)-dependent neutral amino acid transporter ASCT-1. GLAST-1, ASCT-1 and the glutamate transporters GLT-1 and EAAC-1 have strongly similar amino acid sequences. The L-glutamate transporter gene structures might help to understand the correlation of L-glutamate reuptake in neurodegenerative disorders.