The sensitivity of 144 isolates of Vibrio spp isolated from shrimp was compared using common antibiotics and those used in the shrimp industry. The in vitro susceptibility of the isolates was studied using amikacin, ampicillin, carbenicillin, cephalothin, cefotaxime, ceftriaxone, chloramphenicol, gentamicin, netilmicin, nitrofurantoin, pefloxacin, trimethoprim-sulphamethoxazole, enrofloxacin, oxytetracycline and florfenicol. The relationship between the minimum inhibitory concentration and the disk inhibition zone was also studied for some antibiotics.