Neointimal hyperplasia is the most common complication of all forms of arterial reconstructions. This response of the vascular wall to injury is influenced by many factors, especially, but not limited to, by the hemodynamic profile in the area of vascular anastomosis and in its close proximity. To eliminate this negative influence of hemodynamics on progression of neointimal hyperplasia, we tried to develop anastomosis with optimal hemodynamic parameters. In our experimental study we used Particle Image Velocimetry measurement and 3D blood flow simulation for studying flow characteristics for different length and angles of anastomoses. Based on our experimental studies and numerical simulations we believe that anastomosis with smaller angle demonstrates better hemodynamic parameters, optimal angle being less than 30 dg. Length of anastomosis in this smaller angle anastomosis is app. 2-2.5 of native vessel diameter.