Published in
BMJ Publishing Group, BMJ, jan21 3(340), p. b5500-b5500, 2010
DOI: 10.1136/bmj.b5500
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Association between pre-diagnostic circulating vitamin D concentration and risk of colorectal cancer in European populations:a nested case-control study
,
H. Bas Bueno de Mesquita,
Prieto Ferrari,
Franzel J. B. van Duijnhoven,
Teresa Norat,
Tobias Pischon ,
Eugène H. J. M. Jansen,
Nadia Slimani,
Graham Byrnes,
S. Rinaldi,
Anne Tjønneland,
Anja Olsen ,
Kim Overvad ,
Marie-Christine Boutron-Ruault,
Françoise Clavel-Chapelon
and other authors.
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Abstract
Objective. To examine the association between pre-diagnostic circulating vitamin D concentration, dietary intake of vitamin D and calcium, and the risk of colorectal cancer in European populations. Design Nested case-control study. Setting. The study was conducted within the EPIC study, a cohort of more than 520 000 participants from 10 western European countries. Participants: 1248 cases of incident colorectal cancer, which developed after enrolment into the cohort, were matched to 1248 controls. Main outcome measures. Circulating vitamin D concentration (25-hydroxy-vitamin-D, 25-(OH)D) was measured by enzyme immunoassay. Dietary and lifestyle data were obtained from questionnaires. Incidence rate ratios and 95% confidence intervals for the risk of colorectal cancer by 25-(OH)D concentration and levels of dietary calcium and vitamin D intake were estimated from multivariate conditional logistic regression models, with adjustment for potential dietary and other confounders. Results. 25-(OH)D concentration showed a strong inverse linear dose-response association with risk of colorectal cancer (P for trend