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American Chemical Society, Journal of Organic Chemistry, 6(73), p. 2473-2475, 2008

DOI: 10.1021/jo7026883

Wiley-VCH Verlag, ChemInform, 30(39), 2008

DOI: 10.1002/chin.200830160

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Concise Synthesis of 2-Amino-4(3H)-quinazolinones from Simple (Hetero)aromatic Amines

Journal article published in 2008 by Walid Zeghida, Julien Debray, Sabine Chierici, Pascal Dumy ORCID, Martine Demeunynck
This paper was not found in any repository; the policy of its publisher is unknown or unclear.
This paper was not found in any repository; the policy of its publisher is unknown or unclear.

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Abstract

A novel and simple method of preparation of 2-alkylaminoquinazolin-4-ones with fused heteroaromatic rings from easily accessible (hetero)aromatic amines is described. The method is very efficient, and the 2-alkylaminoquinazolinone derivatives are obtained in three steps without chromatographic purification. The key step is the ring closure of the N-protected guanidine intermediates by intramolecular Friedel-Craft's type substitution.