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Elsevier, Farmaco, 11-12(54), p. 713-720
DOI: 10.1016/s0014-827x(99)00077-4
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Synthesis, binding affinity and selectivity of new β1- and β2- adrenoceptor blockers
Journal article published in 1999 by
Vittorio Brizzi,
Marco Francioli,
Mario Brufani,
Luigi Filocamo,
Giancarlo Bruni,
Paola Massarelli 
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Abstract
The synthesis of a new series of sesamol derivatives with beta-adrenergic blocking activity is described. The affinity and selectivity of these compounds for beta 1- and beta 2-adrenoceptors were studied in comparison with those of ICI-118551 and propranolol. Some of the synthesized compounds show very good affinity for the beta 2-receptors of rat lung membranes and two of them provide interesting selectivity.