Dissemin is shutting down on January 1st, 2025

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Springer, Advances in Experimental Medicine and Biology, p. 31-41, 2015

DOI: 10.1007/978-3-319-15774-0_3

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The Role of Il-12 and Type I Interferon in Governing the Magnitude of CD8 T Cell Responses

Journal article published in 2015 by Gabriel R. Starbeck Miller ORCID, John T. Harty
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Antigen-specific CD8 T cells provide an important protective role in response to infection by viruses, intracellular bacteria, and parasites. Pathogen-specific CD8 T cells render this protection by undergoing robust expansion in numbers while gaining the ability to produce cytokines and cytolytic machinery. Creating optimal CD8 T cell responses to infection can be critical for raising sufficient armament to provide protection against invading intracellular pathogens. Although CD8 T cells have protective value, many vaccine strategies tend to focus on creating productive B cell antibody responses to promote immunological protection. Even though antibody responses can be highly protective, coupling optimal CD8 T cell responses with suboptimal B cell responses could provide higher orders of protection than either one on their own. Therefore, a deeper understanding of the pathways that ultimately guide the magnitude of CD8 T cell responses is required to explore this potential therapeutic benefit. The following chapter highlights our current understanding of how inflammatory cytokines regulate the magnitude of CD8 T cell responses.