Dissemin is shutting down on January 1st, 2025

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American Society for Microbiology, Journal of Virology, 8(87), p. 4772-4777, 2013

DOI: 10.1128/jvi.03122-12

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The Frequency of CD127+ Hepatitis C Virus (HCV)-Specific T Cells but Not the Expression of Exhaustion Markers Predicts the Outcome of Acute HCV Infection

Journal article published in 2013 by Eui-Cheol Shin, Su-Hyung Park, Michelina Nascimbeni, Marian Major, Laura Caggiari, Valli de Re, Stephen M. Feinstone, Charles M. Rice, Barbara Rehermann ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT T cells are exhausted and overexpress inhibitory molecules in chronic hepatitis C virus (HCV) infection. It is unclear whether this is the cause or consequence of HCV persistence. By studying serial blood and liver samples of chimpanzees during acute infection, we demonstrate that the early expression of the memory precursor marker CD127 on HCV-specific T cells, but not the expression of inhibitory molecules on those T cells or their ligands in the liver, predicts the outcome of acute infection.