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American Society for Microbiology, Journal of Virology, 8(87), p. 4751-4755, 2013

DOI: 10.1128/jvi.03085-12

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An Attenuated Listeria monocytogenes Vector Primes More Potent Simian Immunodeficiency Virus-Specific Mucosal Immunity than DNA Vaccines in Mice

Journal article published in 2013 by Eung-Jun Im, Erica N. Borducchi, Nicholas M. Provine ORCID, Anna G. McNally, Sufen Li, Fred R. Frankel, Dan H. Barouch
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT A human immunodeficiency virus type 1 (HIV-1) vaccine that induces potent immune responses in the gastrointestinal mucosa would be highly desirable. Here we show that attenuated recombinant Listeria monocytogenes , administered orally utilizing its natural route of infection, induces potent mucosal as well as systemic immune responses in mice. Moreover, these responses can be boosted efficiently with replication-incompetent adenoviral vectors. L. monocytogenes elicited more potent simian immunodeficiency virus (SIV) Gag-specific CD8 + T lymphocyte responses in mucosal compartments than DNA vaccines.