Published in
Bentham Science Publishers, Drug Metabolism Letters, 2(2), p. 138-145
DOI: 10.2174/187231208784041013
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Long Term Treatment with Tetradecylthioacetic Acid Improves the Antioxidant Status in Obese Zucker (fa/fa) Rats
Journal article published in 2008 by
Hege Wergedahl,
Kjetil Berge,
Pavol Bohov,
Karl-Johan Tronstad,
Lise Madsen 
,
Rolf K. Berge
,
Rolf K. Berge
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Abstract
Increased oxidative stress was observed in obese Zucker rats. Treatment of obese rats with tetradecylthioacetic acid for 12 weeks increased the H(2)O(2)-production, but decreased plasma malondialdehyde, changed the serum fatty acid profile, increased liver fatty acid binding protein mRNA, and lowered serum insulin, thereby enhancing the antioxidant defense system.