Published in

Nature Research, Nature, 6162(332), p. 323-327, 1988

DOI: 10.1038/332323a0

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Reshaping human antibodies for therapy

Journal article published in 1988 by Michael Clark ORCID, Lutz Riechmann, Herman Waldmann, Greg Winter
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

A human IgGI antibody has been reshaped for serotherapy in humans by introducing the six hypervariable regions from the heavy- and light-chain variable domains of a rat antibody directed against human lymphocytes. The reshaped human antibody is as effective as the rat antibody in complement and is more effective in cell-mediated lysis of human lymphocytes.