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Instituto Oswaldo Cruz, Ministério da Saúde, Memórias do Instituto Oswaldo Cruz., 2(102), p. 225-228

DOI: 10.1590/s0074-02762007005000002

Instituto Oswaldo Cruz, Ministério da Saúde, Memórias do Instituto Oswaldo Cruz., 2(102)

DOI: 10.1590/s0074-02762007000200017

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Treatment of human acute schistosomiasis with oxamniquine induces an increase in interferon-γ response to Schistosoma mansoni antigens

Journal article published in 2007 by Joelma R. De Souza, Joelma R. de Souza, Clarice Nl L. Morais, Marcílio L. Aroucha, Paulo Jc C. Miranda, Constança S. Barbosa ORCID, Ana Lúcia C. Domingues, Luiz B. Carvalho Junior, Frederico Gc C. Abath, Silvia Ml L. Montenegro
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Patients with acute schistosomiasis were studied before and after oxamniquine treatment. They had been exposed to cercariae 5 to 9 weeks before, and presented compatible clinical manifestations, eosinophilia, and high levels of total IgE. Interferon-gamma (IFN-gamma) and interleukin-4 were measured by ELISA in whole blood samples under soluble egg antigen or soluble adult worm preparation stimulation. After treatment, the reduction of leukocytosis and eosinophilia were not significant, but total IgE levels decreased significantly, in contrast to IFN-gamma levels that were significantly increased. The oxamniquine treatment of acute schistosomiasis patients is followed by an improvement of a Th1 response in vitro. If this response has a protective aspect is unknown, and some investigations need to be realized.