Dissemin is shutting down on January 1st, 2025

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BMJ Publishing Group, Thorax, 5(66), p. 375-382, 2011

DOI: 10.1136/thx.2010.153825

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Bronchoalveolar CD4+ T cell responses to respiratory antigens are impaired in HIV-infected adults

Journal article published in 2011 by Kondwani C. Jambo, Enoch Sepako, Duncan G. Fullerton, David Mzinza ORCID, Sarah Glennie, Adam K. Wright, Robert S. Heyderman, Stephen B. Gordon
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Rationale HIV-infected adults are at an increased risk of lower respiratory tract infections. HIV infection impairs systemic acquired immunity, but there is limited information in humans on HIV-related cell-mediated immune defects in the lung. Objective To investigate antigen-specific CD4+ T cell responses to influenza virus, Streptococcus pneumoniae and Mycobacterium tuberculosis antigens in bronchoalveolar lavage (BAL) and peripheral blood between HIV-infected individuals and HIV-uninfected Malawian adults. Methods We obtained BAL fluid and blood from HIV-infected individuals (n=21) and HIV-uninfected adults (n=24). We determined the proportion of T cell subsets including naive, memory and regulatory T cells using flow cytometry, and used intracellular cytokine staining to identify CD4+ T cells recognising influenza virus-, S pneumoniae- and M tuberculosis-antigens. Main results CD4+ T cells in BAL were predominantly of effector memory phenotype compared to blood, irrespective of HIV status (p