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Oxford University Press, Genetics, 1(179), p. 717-721, 2008

DOI: 10.1534/genetics.107.083154

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A thermodynamic switch for chromosome colocalization

Journal article published in 2008 by Mario Nicodemi ORCID, Barbara Panning, Antonella Prisco
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract A general model for the early recognition and colocalization of homologous DNA sequences is proposed. We show, on thermodynamic grounds, how the distance between two homologous DNA sequences is spontaneously regulated by the concentration and affinity of diffusible mediators binding them, which act as a switch between two phases corresponding to independence or colocalization of pairing regions.