Published in
Elsevier, European Journal of Obstetrics and Gynecology and Reproductive Biology, 2(66), p. 197-199
DOI: 10.1016/0301-2115(96)02410-4
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Trophoblast antigen levels in the first trimester of a trisomy 22 pregnancy
Journal article published in 1996 by
Danielle M. Wheeler,
W. Rohini Edirisinghe,
Frances Petchell,
John L. Yovich 
,
Ashleigh R. Murch,
Douglas M. Saunders,
Michael J. Sinosich
,
Ashleigh R. Murch,
Douglas M. Saunders,
Michael J. Sinosich
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Abstract
We report trophoblast antigen (pregnancy-associated plasma protein-A, PAPP-A; free beta-human chorionic gonadotrophin, F beta hCG) expression in a trimosy 22 pregnancy. Maternal concentrations of these antigens were depressed prior to detection of abnormalities by ultrasonography. Immunohistochemical findings were consistent with depressed marker expression.