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Springer Nature [academic journals on nature.com], Leukemia, 2(29), p. 503-507, 2014

DOI: 10.1038/leu.2014.294

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The Krüppel-like factor 2 transcription factor gene is recurrently mutated in splenic marginal zone lymphoma

Journal article published in 2014 by R. Piva ORCID, S. Deaglio, R. Famà, R. Buonincontri, I. Scarfò, A. Bruscaggin, E. Mereu, S. Serra, V. Spina, D. Brusa, G. Garaffo, S. Monti, M. Dal Bo, R. Marasca ORCID, L. Arcaini and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Splenic marginal zone lymphoma (SMZL) is an indolent B-cell tumor involving the spleen, and is characterized by recurrent deletion of chromosome 7q and biased usage of the immunoglobulin heavy variable (IGHV) allele 1-2*04.(1) Genomic studies have partially unraveled the typical SMZL-coding genome, which is characterized by lesions affecting genes involved in the physiological homeostasis of marginal zone (MZ) B cells, including mutations of NOTCH2.(2-5) However, the full spectrum of lesions that contribute to the malignant transformation of SMZL remains unknown.