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Lippincott, Williams & Wilkins, Epidemiology, Suppl(17), p. S345, 2006

DOI: 10.1097/00001648-200611001-00915

Elsevier, Cancer Letters, 2(237), p. 281-288

DOI: 10.1016/j.canlet.2005.06.010

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The Association between Microsomal Epoxide Hydrolase Genotypes and Esophageal Squamous-Cell-Carcinoma in Taiwan: Interaction between Areca Chewing and Smoking

Journal article published in 2006 by Ying-Chu Lin, 吳登強;李章銘;許宏基;高英隆;吳明蒼, Deng-Chyang;Lee Jang-Ming;Hsu Hon-Ki;Kao Ein-Long;Wu Ming-Tsang Wu, Jang-Ming Lee ORCID, Hon-Ki Hsu, Ein-Long Kao, Chien-Hui Yang, Ming-Tsang Wu
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Abstract

One hundred and forty-five ESCC patients and 352 controls were recruited from three hospitals in Taiwan to determine the association between esophageal squarnous-cell-carcinoma( ESCC) and microsomal epoxide hydrolase (mEH) genotypes at Thy113His and His139Arg. Stratified by their exposures, the His113His genotype was a significant protective factor for ESCC in areca chewers and tobacco smokers. Stratified by His 113 polymorphisms, the risk of contracting ESCC for participants with His113 His who chewed areca and smoked was> 50% less than for those with Thy113 Thy. We suggest that the mEH His113His genotype can differentiate the association between smoking, areca chewing, and ESCC. (c) 2005 Elsevier Ireland Ltd. All rights reserved. ; 附設醫院外科部 ; 醫學院附設醫院 ; 期刊論文