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Springer, Histochemistry and Cell Biology, 6(129), p. 687-693, 2008

DOI: 10.1007/s00418-008-0416-9

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Structure and function of mammalian cilia

Journal article published in 2008 by Peter Satir, Soren T. Christensen ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

In the past half century, beginning with electron microscopic studies of 9 + 2 motile and 9 + 0 primary cilia, novel insights have been obtained regarding the structure and function of mammalian cilia. All cilia can now be viewed as sensory cellular antennae that coordinate a large number of cellular signaling pathways, sometimes coupling the signaling to ciliary motility or alternatively to cell division and differentiation. This view has had unanticipated consequences for our understanding of developmental processes and human disease.