A facile synthesis for the coating of magnetic nanoparticles with large-pore, uniform mesoporous silica shells is reported. The applied procedure provides easily separable core-shell particles with discrete morphology after all production steps, crucial for any biomedical application. The large-pore sizes obtained (7nm) paves the way for the porous shell to host also larger biomolecules than possible for standard mesoporous silica-coated particles with 3nm pores, suitable mostly for hosting small-molecular drugs. Moreover, the synthesis is performed under neutral conditions, which prevent the magnetite (iron oxide) core from leaching/dissolving into the synthesis liquid. The same synthesis regime adapted to the corresponding standard acidic large-pore mesoporous silica synthesis conditions moreover proved to be unsuccessful, which may be a reason why syntheses of large-pore silica shells leading to discrete particles instead of particle agglomerates has to our knowledge not previously been reported in the literature.