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Elsevier, Tuberculosis, (88), p. S19-S24, 2008

DOI: 10.1016/s1472-9792(08)70033-7

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The many roads to essential genes

Journal article published in 2008 by Jun-Rong Wei, Eric J. Rubin ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Antibiotics target functions that are required for bacterial growth and survival. As genetic tools for studying Mycobacterium tuberculosis continue to improve we are increasingly able to identify genes that encode these important effectors. Here we review the strategies that have been used to identify and validate essential genes in mycobacteria and look forward to possible future advances.