Published in
Taylor and Francis Group, OncoImmunology, 8(2), p. e25594
DOI: 10.4161/onci.25594
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- ORCID
- Taylor and Francis Group | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [europepmc.org] | PDF
- [www.researchgate.net] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
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Biological insights into BRAFV600mutations in melanoma patient
Journal article published in 2013 by
Giuseppina Improta,
Giuseppe Pelosi,
Elena Tamborini 
,
Marco Donia ,
Mario Santinami,
Filippo de Braud,
Filippo Fraggetta
,
Marco Donia ,
Mario Santinami,
Filippo de Braud,
Filippo Fraggetta
This paper is made freely available by the publisher.
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Abstract
Some experimental evidence indicates that uncommon BRAF mutations consisting in the substitution of 2 adjacent nucleotides within codon 600 are in a cis configuration and associate with BRAF gene amplification. These findings suggest that BRAF(V600) mutations are unlikely to occur as homozygous alterations in clinical melanoma samples, with gene amplification perhaps contributing to mask the heterozygous state.