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BMJ Publishing Group, BMJ, apr15 7(348), p. g2301-g2301

DOI: 10.1136/bmj.g2301

Lippincott, Williams & Wilkins, Obstetric Anesthesia Digest, 1(35), p. 6-7, 2015

DOI: 10.1097/01.aoa.0000460375.20198.f1

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Chronic hypertension and pregnancy outcomes: systematic review and meta-analysis

Journal article published in 2014 by Kate Bramham, Bethany Parnell, Catherine Nelson-Piercy, Paul T. Seed ORCID, Lucilla Poston ORCID, Lucy C. Chappell
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

To provide an accurate assessment of complications of pregnancy in women with chronic hypertension, including comparison with population pregnancy data (US) to inform pre-pregnancy and antenatal management strategies. Systematic review and meta-analysis. Embase, Medline, and Web of Science were searched without language restrictions, from first publication until June 2013; the bibliographies of relevant articles and reviews were hand searched for additional reports. Studies involving pregnant women with chronic hypertension, including retrospective and prospective cohorts, population studies, and appropriate arms of randomised controlled trials, were included. Pooled incidence for each pregnancy outcome was reported and, for US studies, compared with US general population incidence from the National Vital Statistics Report (2006). 55 eligible studies were identified, encompassing 795,221 pregnancies. Women with chronic hypertension had high pooled incidences of superimposed pre-eclampsia (25.9%, 95% confidence interval 21.0% to 31.5 %), caesarean section (41.4%, 35.5% to 47.7%), preterm delivery