Laser action using non-coupled excitation and detection of microspheres made of Nd3+ doped barium–titanium–silicate glass has been demonstrated and measured. The microspheres have also been successfully deposited over Si3N4 strip waveguides with a SiO2 separation layer, thus enabling the laser emission extraction onto a CMOS compatible photonic circuit. The dynamics of the lasing wavelength and intensity has been studied as a function of the pump power and interpreted in terms of thermal effects generated through non-radiative recombination of the excited ions.