Myosins exist that are fused to domains that harbour signalling activities. Class III myosins (NINAC) are protein kinases that play important roles in phototransduction. Class IX myosins inactivate the small G-protein Rho that acts as molecular switch. Because these myosins interact via their myosin head domain with actin filaments, they link signal transduction to the actin cytoskeleton. The exact motor properties of these myosins, however, remain to be determined.