Sexual minority youth [SMY] are a population who experience considerable stress related to their sexual identities. Previous investigations have identified individual risk factors that contribute to suicide among SMY, yet little research has focused on cumulative stressors that may exacerbate negative outcomes for multiethnic sexual minority youth [MSMY]. This study used hierarchical logistic regression to explore the relationship between cumulative risks and their relationship to self-reported suicide risk for MSMY. The community-based clinical sample (n = 137) reported high co-occurrence of risks, with an average of 9. Overall, MSMY with a higher number of cumulative risk factors were twice as likely to express self-reported suicide risk. Specifically, experiencing chronic illness and physical or sexual abuse resulted in threefold higher odds of self-reported suicide risk among MSMY. These findings address a gap in the literature about the relationship of cumulative and specific stressors to the self-reported suicide risk for an understudied, vulnerable population.