ZET Akut miyokard infarktüsü geçiren nondiyabetik hastalarda glikoz-insülin-potasyum tedavisinin etkinli¤i Amaç: Çal›flmam›zda akut miyokard infarktüsü (AM‹) geçiren nondiyabetik hastalarda standart tedavilere ek olarak verdi¤imiz glikoz-insü-lin-potasyum (G‹K) tedavisinin etkinli¤i araflt›r›ld›. Gereç ve Yöntem: Çal›flmam›za Taksim E¤itim ve Araflt›rma Hastanesi Koroner Yo¤un Bak›m Ünitesi'nde Ocak 2005-Haziran 2005 tarihle-ri aras›nda AM‹ tan›s› ile takip edilen nondiyabetik 29 hasta al›nd›. Standart tedavilere ek olarak hastalar›n 14'üne G‹K solüsyonu verildi, 15'ine ise verilmedi. ‹ki grup aras›nda kardiyak enzim yükselme h›z› bak›m›ndan fark olup olmad›¤› araflt›r›ld›. Diyabetes mellitus tan›s›, anamnezinde antidiyabetik ilaç kullanmas› veya açl›k kan flekerinin iki kez 126 ve üzerinde olmas› veya tokluk kan flekerinin 200'ün üze-rinde ve diyabete ait semptomlar›n olmas› ile konuldu. Miyokard infarktüsü tan›s› klinik de¤erlendirme, elektrokardiyografi ve kardiak en-zim yüksekli¤i ile konuldu. Baflvuruda 6, 12 ve 24. saatte kreatin fosfokinaz (CPK), CPK-MB, myoglobin, Troponin I ile C-reaktif protein (CRP) düzeylerine bak›ld›. Lipid profili incelendi. Bulgular: Gruplar aras›nda yafl, vücut a¤›rl›¤›, boy, baflvuru saati ve lipid profili aç›s›ndan fark yoktu. Baflvuru, 6 ve 12. saat CRP düzeyleri iki grup aras›nda istatistiksel aç›ndan anlaml› fark oluflturmazken 24. saat de¤eri G‹K verilen grupta 22.56±12.95 mg/dL iken verilmeyen grupta 78.92±69.4 mg/dL olup p 0.013 bulundu. Dunn's Çoklu Karfl›laflt›rma Testi'ni kullanarak yapt›¤›m›z de¤erlendirmede G‹K verilen grup-ta Troponin I'n›n 0 ile 6. ve 12. saat de¤erleri aras›nda istatistiksel olarak anlaml› bir fark olmas›na karfl›n (p<0.05 ve p<0.001) G‹K verilme-yen grupta bu fark yoktu (p>0.05). Gelifl ve 24. saat de¤erlerine bak›ld›¤›nda ise her iki grupta da p<0.05 bulundu. Sonuç: G‹K verdi¤imiz grupta miyokardiyal hasar belirteçlerinin bir k›sm›nda düflme oldu¤unu belirledi¤imiz çal›flmam›zda G‹K solüsyonu-nun diyabetik hastalar kadar nondiyabetik hastalarda da yararl› olabilece¤i kan›s›na vard›k. Anahtar kelimeler: Miyokard infarktüsü, glikoz, insülin, potasyum ABSTRACT Effectiveness of glucose-insulin–potassium treatment in nondiabetic patients with acute myocardial infarction Objective: Glucose-insulin-potassium (GIK) treatment given additional to standard therapy effectiveness was investigated in nondiabetic patients with acute myocardial infarction. Material and Method: 29 nondiabetic patients with acute myocardial infarction participated between January and June 2005 in Taksim Training and Research Hospital Coronary Care Unit. Besides standard therapy 14 patients received GIK solution while 15 patients did not. The cardiac enzyme increasing velocity differences were investigated. All patients investigated were nondiabetics. Myocardial infarction was diagnosed by chest pain, electrocardiography and cardiac enzyme assessments. Blood samples for creatin phosphokinase, CPK-MB, myoglobine, Troponin-I and C-reactive protein (CRP) were enrolled at index and further after 6th, 12th and 24th hours. Results: No difference was detected regarding age, body weight, height, application time and lipid profiles between two groups. Although index of 6th and 12th hour controls showed no difference, 24th hour values showed statistically significant difference with a p=0.0013. CRP level in GIK group was 22.56±12.95 mg/dL and 78.92±69.94 mg/dL in non-GIK group. In our assessment using DUNN's multiple comparison test, although in the group receiving GIK, there was a statistically significant difference accordingly Troponin-I initial and 6th, 12th hours; there was no difference in the given GIK and non GIK group. In comparison of the CRP levels at index and at 24th hour p values were found less than 0,05 (p<0,05) in both groups. Conclusion: In our study, we realized that in the group given GIK; some of the myocardial injury markers were decreasing and finally decided that GIK solution could be beneficial in diabetic and nondiabetic patients.