Spectral-domain optical coherence phase microscopy for quantitative phase-contrast imaging
Journal article published in 2005 by
Chulmin Joo 
,
Taner Akkin,
Barry Cense,
Boris H. Park,
Johannes F. de Boer
,
Taner Akkin,
Barry Cense,
Boris H. Park,
Johannes F. de Boer
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Abstract
We describe a novel microscopy technique for quantitative phase-contrast imaging of a transparent specimen. The technique is based on depth-resolved phase information provided by common path spectral-domain optical coherence tomography and can measure minute phase variations caused by changes in refractive index and thickness inside the specimen. We demonstrate subnanometer level path-length sensitivity and present images obtained on reflection from a known phase object and human epithelial cheek cells.