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Wiley, European Journal of Organic Chemistry, 24(2002), p. 4228-4233, 2002

DOI: 10.1002/1099-0690(200212)2002:24<4228::aid-ejoc4228>3.0.co;2-n

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Synthesis of Triple Helix Forming Oligonucleotides with a Phenanthroline Moiety into the 3′-3′ Inversion Site of Polarity

Journal article published in 2002 by Veronica Esposito, Aldo Galeone ORCID, Luciano Mayol ORCID, Giorgia Oliviero, Antonio Randazzo, Michela Varra
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This paper is available in a repository.

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Abstract

A protocol for the synthesis of triplex forming oligonucleotides containing a chelating molecule in the 3′-3′ inversion site of polarity is reported. A number of 16-mers have been synthesized and UV spectroscopy employed to evaluate the stability of their triple helix complexes with the pertinent double-strand oligonucleotide targets. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2002)