Dissemin is shutting down on January 1st, 2025

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Nature Research, Nature Genetics, 11(39), p. 1318-1320, 2007

DOI: 10.1038/ng.2007.4

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Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridgeback dogs

Journal article published in 2007 by Nicolette H. C. Salmon Hillbertz, Magnus Isaksson, Elinor K. Karlsson ORCID, Eva Hellmén, Gerli Rosengren Pielberg, Peter Savolainen, Claire M. Wade ORCID, Henrik von Euler, Ulla Gustafson, Åke Hedhammar, Mats Nilsson, Kerstin Lindblad-Toh, Leif Andersson, Göran Andersson
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The dorsal hair ridge in Rhodesian and Thai Ridgeback dogs is caused by a dominant mutation that also predisposes to the congenital developmental disorder dermoid sinus. Here we show that the causative mutation is a 133-kb duplication involving three fibroblast growth factor (FGF) genes. FGFs play a crucial role in development, suggesting that the ridge and dermoid sinus are caused by dysregulation of one or more of the three FGF genes during development.