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American Association for the Advancement of Science, Science, 5657(303), p. 540-543, 2004

DOI: 10.1126/science.1091403

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A Map of the Interactome Network of the Metazoan C. elegans

Journal article published in 2004 by Siming Li, Christopher M. Armstrong, Nicolas Bertin ORCID, Hui Ge, Stuart Milstein, Mike Boxem, Pierre-Olivier Vidalain, Jing-Dong J. Han, Alban Chesneau, Tong Hao, Debra S. Goldberg, Ning Li, Monica Martinez, Jean-François Rual, Philippe Lamesch and other authors.
This paper is available in a repository.
This paper is available in a repository.

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Abstract

To initiate studies on how protein-protein interaction (or “interactome”) networks relate to multicellular functions, we have mapped a large fraction of the Caenorhabditis elegans interactome network. Starting with a subset of metazoan-specific proteins, more than 4000 interactions were identified from high-throughput, yeast two-hybrid (HT=Y2H) screens. Independent coaffinity purification assays experimentally validated the overall quality of this Y2H data set. Together with already described Y2H interactions and interologs predicted in silico , the current version of the Worm Interactome (WI5) map contains ∼5500 interactions. Topological and biological features of this interactome network, as well as its integration with phenome and transcriptome data sets, lead to numerous biological hypotheses.