The presence of organic coatings on aerosols may have important consequences to the atmospheric chemistry, in particular to the N2O5 heterogeneous hydrolysis. This is demonstrated by recent experiments which show that the uptake of N2O5 by aqueous aerosols is slowed considerably when an organic coating consisting of monoterpene oxidation products is added on the particles. To treat the mechanisms behind the suppression, an extension of the resistor model, which has been widely applied in investigation of the heterogeneous uptake by aerosols, was derived. The extension accounts for dissolution, diffusion, and chemical reactions in a multilayered organic coating, and it provides a parametrization for the heterogeneous uptake by organic-coated aerosols that can be applied in large-scale models. Moreover, the framework was applied to interpret the findings regarding the decreased uptake of N2O5 by the organic-coated aerosols. Performed calculations suggested that the reaction rate constant of N2O5 in the coating is decreased by 3-5 orders of magnitude, in addition to which the product of the solubility of N2O5 and its diffusion coefficient in the coating is reduced more than an order of magnitude compared to the corresponding value for the aqueous phase. The results suggest also that the accommodation coefficient of N2O5 to such coatings is no more than a factor of 2 smaller than that to pure water surfaces. Finally, the relevance of the results to the atmospheric N2O5 heterogeneous hydrolysis is discussed and implications to planning further laboratory studies focusing on secondary organic aerosol formation are pointed out.