Published in
American Association for the Advancement of Science, Science Translational Medicine, 229(6), 2014
DOI: 10.1126/scitranslmed.3008763
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Abstract
The pathobiology-based approach to research and development has been the dominant paradigm for successful drug discovery over the last decades. We propose that the molecular and cellular events that govern a resolving, rather than an evolving, disease may reveal new druggable pathways.