Published in
BioMed Central, BMC Cancer, 1(13), 2013
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Reproductive factors and risk of hormone receptor positive and negative breast cancer: a cohort study
,
Kim Overvad ,
Laure Dossus,
Agnès Fournier ,
Françoise Clavel-Chapelon,
Verena Grote,
Heiner Boeing,
Krasimira Aleksandrova,
Antonia Trichopoulou,
Pagona Lagiou,
Dimitrios Trichopoulos
and other authors.
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Abstract
Abstract Background The association of reproductive factors with hormone receptor (HR)-negative breast tumors remains uncertain. Methods Within the EPIC cohort, Cox proportional hazards models were used to describe the relationships of reproductive factors (menarcheal age, time between menarche and first pregnancy, parity, number of children, age at first and last pregnancies, time since last full-term childbirth, breastfeeding, age at menopause, ever having an abortion and use of oral contraceptives [OC]) with risk of ER-PR- (n = 998) and ER+PR+ (n = 3,567) breast tumors. Results A later first full-term childbirth was associated with increased risk of ER+PR+ tumors but not with risk of ER-PR- tumors (≥35 vs. ≤19 years HR: 1.47 [95% CI 1.15-1.88] p trend