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Optica, Optics Letters, 19(36), p. 3894, 2011

DOI: 10.1364/ol.36.003894

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Ultrathin side-viewing needle probe for optical coherence tomography

Journal article published in 2011 by X. Yang, B. C. Quirk, R. A. McLaughlin, D. D. Sampson ORCID, R. W. Kirk, D. Lorenser
This paper is available in a repository.
This paper is available in a repository.

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Abstract

We present the smallest reported side-viewing needle probe for optical coherence tomography (OCT). Design, fabrication, optical characterization, and initial application of a 30-gauge (outer diameter 0.31 mm) needle probe are demonstrated. Extreme miniaturization is achieved by using a simple all-fiber probe design incorporating an angle-polished and reflection-coated fiber-tip beam deflector. When inserted into biological tissue, aqueous interstitial fluids reduce the probe's inherent astigmatism ratio to 1.8, resulting in a working distance of 300 μm and a depth-of-field of 550 μm with beam diameters below 30 μm. The needle probe was interfaced with an 840 nm spectral-domain OCT system and the measured sensitivity was shown to be only 7 dB lower than that of a comparable galvo-scanning sample arm configuration. 3D OCT images of lamb lungs were acquired over a depth range of ~600 μm, showing individual alveoli and bronchioles.