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Wiley, Advanced Healthcare Materials, 13(4), p. 1956-1960, 2015

DOI: 10.1002/adhm.201500245

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Installing Multifunctionality on Titanium with RGD‐Decorated Polyurethane‐Polyurea Roxithromycin Loaded Nanoparticles: Toward New Osseointegrative Therapies

Journal article published in 2015 by Pau Rocas, Mireia Hoyos-Nogués, Josep Rocas, José M. Manero, Javier Gil, Fernando Albericio, Carlos Mas-Moruno ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

A novel class of polyurethane-polyurea nanoparticles (PUUa NPs) to install multifunctionality on biomaterials is presented. Biofunctionalization of titanium with roxithromycin loaded RGD-decorated PUUa NPs results in an outstanding improvement of osteoblast adhesion and strong suppression of bacterial attachment. This strategy represents a powerful approach to enhance the osseointegration of implant materials.