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American Chemical Society, Journal of Organic Chemistry, 5(74), p. 2171-2174, 2009

DOI: 10.1021/jo8023889

Wiley-VCH Verlag, ChemInform, 30(40), 2009

DOI: 10.1002/chin.200930144

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Diastereoselective Synthesis of Polycyclic Acetal-Fused Pyrano[3,2-c]pyran-5(2H)-one Derivatives

Journal article published in 2009 by Ram Sagar, Jongmin Park ORCID, Minseob Koh ORCID, Seung Bum Park
This paper is available in a repository.
This paper is available in a repository.

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Abstract

A facile and efficient diastereoselective one-pot synthesis of polycyclic acetal-fused pyrano[3,2-c]pyrane-5(2H)-one was achieved through the annulation reaction of 2-C-formyl glycals with various 4-hydroxycoumarins and 4-hydroxy-6-methyl-2H-pyran-2-one. The asymmetric induction was significantly influenced by the C-4 stereogenic center of 2-C-formyl glycals. The resulting polycyclic acetal-fused pyranopyrones demonstrated anticancer activities.