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Springer Nature [academic journals on nature.com], Cell Research, 11(24), p. 1286-1287, 2014

DOI: 10.1038/cr.2014.101

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Detecting “different”: Pyrin senses modified GTPases

Journal article published in 2014 by Marcel R. de Zoete, Richard A. Flavell ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Pathogenic bacteria secrete effector proteins that target host cell Rho GTPases to manipulate the actin cytoskeleton. A recent study in Nature identifies the Pyrin inflammasome as a sensor of this pathogenic process.