Every five-year plan of each advanced country in the World includes major investments toward medical care. Consequently, vast improvements have taken place, bringing in precise robotic assistance in surgery and spectacular tools for the early detection of a large number of diseases. Advanced genomics and proteomics have ushered in promises for personalized medicine for cancer patients. Yet, the most advanced countries in the World still witness the highest proportion of age-adjusted incidence of brain cancer. Here we submit an overview of the reported etiology, genetics, and epigenetics that appear to be causal to cancers, especially for brain cancers. We discuss in some detail the use and usefulness of simple natural products such as curcumin to minimize the probability of developing cancer and to counteract existing cancers, even those as deadly as primary brain tumors. In this context we address the argument that brain cancers are more of a metabolic rather than a genetic disease and then discuss the acute need for new strategies for cancer therapy. Based on the findings from many laboratories including ours, we end this review advocating strongly for an effort to follow the example of Mother Nature and develop therapeutic strategies involving relatively safe food-derived anticancer agents.