Synthesis of New Acadesine (AICA-riboside) Analogues Having Acyclic D-Ribityl or 4-Hydroxybutyl Chains in Place of the Ribose
Journal article published in 2013 by
Stefano D'Errico,
Giorgia Oliviero,
Nicola Borbone,
Jussara Amato,
Vincenzo Piccialli,
Michela Varra,
Luciano Mayol 
,
Gennaro Piccialli
,
Gennaro Piccialli
This paper is made freely available by the publisher.
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Abstract
The antiviral activity of certain acyclic nucleosides drew our attention to the fact that the replacement of the furanose ring by an alkyl group bearing hydroxyl(s) could be a useful structural modification to modulate the biological properties of those nucleosides. Herein, we report on the synthesis of some novel acadesine analogues, where the ribose moiety is mimicked by a d-ribityl or by a hydroxybutyl chain.