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Wiley, Immunological Reviews, 1(251), p. 125-142, 2012

DOI: 10.1111/imr.12013

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Transfer of extracellular vesicles during immune cell-cell interactions

Journal article published in 2012 by Cristina Gutiérrez-Vázquez, Carolina Villarroya-Beltri, María Mittelbrunn, Francisco Sánchez-Madrid ORCID
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This paper is available in a repository.

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Abstract

The transfer of molecules between cells during cognate immune cell interactions has been reported, and recently a novel mechanism of transfer of proteins and genetic material such as small RNA between T cells and antigen-presenting cells (APCs) has been described, involving exchange of extracellular vesicles (EVs) during the formation of the immunological synapse (IS). EVs, a term that encompasses exosomes and microvesicles, has been implicated in cell-cell communication during immune responses associated with tumors, pathogens, allergies, and autoimmune diseases. This review focuses on EV transfer as a mechanism for the exchange of molecules during immune cell-cell interactions.